半岛bd体育手机客户端 说明
一般描述
Pro-opiomelanocortin (POMC), a complex pro-peptide is expressed in hypothalamus, pituitary gland, skin and the immune system. This gene is located on human chromosome 2p23.3.
免疫原
synthetic α-MSH peptide conjugated to bovine serum albumin.
应用
Anti-α-MSH antibody produced in rabbit has been used in:
生化/生理作用
α-MSH (melanocyte stimulating hormone) and melanocortin-4-receptor (MC4R) are key signaling components in the control of energy homeostasis and of the hypothalamic response to obesity. Mutations that reduce the functional activity of -MSH lead to obesity in mammals and mice lacking the MC4 receptor (MC4R-/-) are hyperphagic and very obese, indicating that -MSH signaling transduced by MC4-R limits food intake and body fat mass.
α-Melanocyte Stimulating Hormone (α-MSH) stimulates the production of melanin in melanocytes and induced pigmentation and skin darkening. It increases the activity of tyrosinase that induces melanogenesis. α-MSH has potent anti-inflammatory effects and is also a neuromodulator. Analogs of α-MSH may be used to study melanogenesis and neuromodulation.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD03454727 |
| NACRES | NA.46 |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 1664.9 kDa |
| species reactivity | human |
| technique(s) | ELISA: 1:4,000 microarray: suitable |
| UniProt登记号 | P01189 |
| 运输 | dry ice |
| 储存温度 | ?20℃ |
| Gene Information | human ... POMC(5443) |
Sigma-Aldrich
m.cnreagent.com
