Anti-Cdk1 (p34^cdc2) antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

The gene Cyclin-dependent kinase 1 (CDK1) is mapped to human chromosome 10q21.1. The protein localizes in the cytoplasm and the nucleus. CDK1 is also popularly called as CDC2.

免疫原

synthetic peptide corresponding to amino acids 263-287 of the C-terminus of mouse cdk1/cdc2.

应用

Anti-Cdk1 (p34cdc2) antibody produced in rabbit is suitable for immunoprecipitation and western blot (chemiluminescent) at a dilution of 1:500-1:2,000 using mouse 3T3 cell lysates.

生化/生理作用

Cyclin-dependent kinase 1 (CDK1) plays a vital role in the control of eukaryotic cell cycle by modulating the centrosome cycle and the onset of mitosis. It promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. It is essential for development of early embryonic stage. The antibody may cross-react with other cdc2-like kinase. CDK1 is a component of M-phase promoting factor. CDK1 interacts with FAC (Fanconi anemia group C protein) and the binding is important for normal G2/M progression. Similarly, Cep63 binds and recruits Cdk1 to centrosomes, thereby regulating mitotic entry. CDK2 also foms a complex with cyclin E, cyclin A and cyclin D.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD00239719
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	200
偶联物	unconjugated
抗体形式	whole antiserum
antibody product type	primary antibodies
克隆	polyclonal
分子量	antigen 34 kDa
包含	0.05% sodium azide as preservative
species reactivity	human (predicted), rat (predicted), mouse
technique(s)	immunoprecipitation (IP): suitable western blot (chemiluminescent): 1:500-1:2,000 using mouse 3T3 cell lysates
运输	dry ice
储存温度	?20℃
Gene Information	human ... CDC2(983) mouse ... Cdc2a(12534) rat ... Cdc2(54237)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves