SGK1 (δ1-60, S422D), active human

半岛bd体育手机客户端 说明

一般描述

The serum- and glucocorticoid-regulated kinase (SGK1) is a member of the AGC kinase family and the gene encoding it is localized on human chromosome 6q23.

生化/生理作用

The serum- and glucocorticoid-regulated kinase (SGK1) has a role in the hormonal regulation of ion channels and pumps. It has been associated with cancers. The protein modulates nitric oxide production by activating NO synthase. SGK1 protects cells from apoptosis and oxidative stress.
Kinase assays.

单位定义

One unit of SGK1 = 1 nmol phosphate incorporated into crosstide substrate peptide in one minute.

外形

Solution in 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 0.15 M NaCl, 0.03% Brij^?L23, 1 mM benzamidine, 0.2 mM PMSF. and 270 mM sucrose.

法律信息

Brij is a registered trademark of Croda International PLC

基本信息

MDL编号	MFCD03458482
NACRES	NA.32

半岛bd体育手机客户端 性质

质量水平	200
重组	expressed in baculovirus infectedSf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged)
形式	buffered aqueous solution
分子量	~48 kDa by SDS-PAGE
UniProt登记号	O00141
运输	dry ice
储存温度	?70℃
Gene Information	human ... SGK1(6446)