半岛bd体育手机客户端 说明
一般描述
A potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER2 (neu/ErbB2; IC50= 0.35 ?M) relative to HER1 (IC50= 19 ?M) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185neu.
A potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER-2 (neu/erbB-2, IC50= 0.35 ?M) relative to HER-1 (IC50= 19 ?M) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances the chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185neu.
包装
2 mg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Target IC50: 0.35 ?M against HER2
Product does not compete with ATP.
Primary Target
HER2
Reversible: yes
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2-3 months at -20°C.
其他说明
Ashton, J.M., et al. 2012.Cell Stem Cell11,359.
Tsai, C.M., et al. 1996.Cancer Res.56,1068.
Levitzki, A., and Gazit, A. 1995.Science267,1782.
Osherov, N., et al. 1993.J. Biol. Chem.268,11134.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C19H15N3O3S2 |
| 分子量 | 397.47 |
| MDL编号 | MFCD01074971 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥94% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | yellow |
| 溶解性 | DMSO: 10 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
