半岛bd体育手机客户端 说明
一般描述
A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC50= 2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110α, p110β, p110δ, p110γ, PI3-KC2β, mTORC1, and mTORC2, respectively). It inhibits ATR and ATM only at much higher concentrations (IC50= 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 ?M. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines bothin vitroandin vivo.
包装
2 mg in Plastic ampoule
Packaged under inert gas
警告
Toxicity: Irritant (B)
外形
A 10 mM (2 mg/574 ?l) solution of PI-103 (Cat. No. 528100) in DMSO.
重悬
Following initial thaw, aliquot and freeze (-20°C).
其他说明
Raynaud, F.I., et al. 2007.Cancer Res.67,5840.
Fan, Q.W., et al. 2006.Cancer Cell9,341.
Knight, Z.A., et al. 2006.Cell125,733.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C19H16N4O3 |
| 分子量 | 348.36 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 2 |
| 闪点(F) | 188.6 °F - (Dimethylsulfoxide) |
| 闪点(C) | 87 ℃ - (Dimethylsulfoxide) |
m.cnreagent.com
