半岛bd体育手机客户端 说明
一般描述
A cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50= 13 nM; Ki= 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50= 2.5, 9.3, 16.6 ?M for DNA-PK, mTOR, PI 3-K, respectively; IC50>100 ?M for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 ?M. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents.
包装
2 mg in Glass bottle
Packaged under inert gas
警告
Toxicity: Irritant (B)
外形
A 10 mM (2 mg/506 ?l) solution of ATM Kinase Inhibitor (Cat. No. 118500) in DMSO.
重悬
Following initial thaw, aliquot and freeze (-20°C).
其他说明
Pereg, Y., et al. 2005.Proc. Natl. Acad. Sci. USA102,5056.
Lau, A., et al. 2005.Nat. Cell Biol.7,493.
Hickson, I., et al. 2004.Cancer Res.64,9152.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C21H17NO3S2 |
| 分子量 | 395.49 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
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