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位置: 首页> 品牌> Sigma-Aldrich> Akt Inhibitor VII, TAT-Akt-in-Calbiochem

Akt Inhibitor VII, TAT-Akt-in-Calbiochem

品牌
Sigma-Aldrich
货号
124014
规格纯度
The Akt Inhibitor VII, TAT-Akt-incontrols the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
价格
6127.99 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Akt Inhibitor VII, TAT- Akt-in-Calbiochem
H- YGRKKRRQRRR-AVTDHPDRLWAWEKF-OH, TAT-TCL1 1 0 - 2 4
H- YGRKKRRQRRR-AVTDHPDRLWAWEKF-OH, TAT-TCL1 1 0 - 2 4
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable and reversible version of the Akt Inhibitor VI,Akt-in(Cat. No. 124013) fused with the protein transduction domain TAT. Selectively inhibits the phosphorylation of Akt selectively in HEK 293 and QRsP-11 fibrosarcoma cells stimulated with PDGF (complete inhibition at ~50 ?M) with minimal inhibition towards PKA, PKC, PDK1, p42/44 MAPK, or p38 MAPK. Shown to prevent the proliferation of T4 cells and tumor growth in syngeneic C57BL/6 mice at 2 ?M/mouse without any adverse effect.
A cell-permeable and reversible version of the Akt Inhibitor VI,Akt-in(Cat. No. 124013) fused with the protein transduction domain TAT that displays antitumor properties. Inhibits the phosphorylation of Akt selectively in HEK 293 and QRsP-11 fibrosarcoma cells stimulated with PDGF (complete inhibition at ~50 ?M) with minimal inhibition towards PKA, PKC, PDK1, p42/44 MAPK, or p38 MAPK. Shown to prevent the proliferation of T4 cells, and tumor growth in syngeneic C57BL/6 mice.

包装

2 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Target IC50: 50 ?M against Akt
Reversible: yes

警告

Toxicity: Carcinogenic / Teratogenic (D)

序列

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C152H239N55O36
分子量 3412.87

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
desiccated (hygroscopic)
颜色 white
溶解性 water: 1 mg/mL
运输 ambient
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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