半岛bd体育手机客户端 说明
一般描述
The gene Early Endosome Antigen 1 (EEA1) encodes for around 1400 amino acid protein. It is a peripheral membrane protein associated with the cytoplasmic face of early endosomes. EEA1 is a autoantigen associated with subacute cutaneous systemic lupus erythematosus and is a coiled-coil protein localized to early endosomes and cytosol.
免疫原
Immunogen Sequence: GI # 4503469, sequence 307-417
Recombinant early endosome antigen 1, 162kD
应用
Anti-EEA1 antibody produced in chicken is suitable for immunocytochemistry and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
Early Endosome Antigen 1 (EEA1) controls vesicle fusion during endocytosis. In neurons, it is involved in recycling of synaptic vesicles and neurotransmitter receptors. Patients with neurological deficits develop EEA1 autoantibodies. Mutation in EEA1 gene leads to susceptibility to diabetes in the Japanese population. Phosphatidylinositol 3-phosphate (PtdIns(3)P) is essential for the localization and function of EEA1.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
半岛bd体育手机客户端 性质
生物来源 | chicken |
质量水平 | 200 |
偶联物 | unconjugated |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
形式 | buffered aqueous solution |
species reactivity | human |
manufacturer/tradename | Genway 15-288-21443A |
technique(s) | immunocytochemistry: suitable western blot: suitable |
NCBI登记号 | NP_003557.1 |
UniProt登记号 | Q15075 |
运输 | wet ice |
储存温度 | ?20℃ |
Gene Information | human ... EEA1(8411) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
Sigma-Aldrich