Anti-RAD51 antibody produced in mouse

半岛bd体育手机客户端 说明

一般描述

The protein encoded by this gene is a member of the RAD51 protein family. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq) The RAD51 gene is located on human chromosome 15q15.1.

免疫原

RAD51 (NP_002866.2, 1 a.a. ~ 339 a.a) full-length human protein.
Sequence
MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD

应用

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Anti-RAD51 antibody produced in mouse has been used in Western blot analysis and Immunohistochemistry.

生化/生理作用

RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein replication protein A (RPA) and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage.
RAD51 specifically repairs double stranded breaks in the DNA. Upregulation of RAD51 is observed in a number of tumors and indicates poor prognosis. Rad51 induces G0/G1 to S phase transition in cell cycle. Therefore, inhibition of RAD51 reduces the progression of cancer in cases such as cervical cancer.

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
偶联物	unconjugated
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	antigen ~37 kDa
species reactivity	rat, human, mouse
technique(s)	immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable western blot: 1 μg/mL
NCBI登记号	NM_002875
UniProt登记号	Q06609
运输	dry ice
储存温度	?20℃
Gene Information	human ... RAD51(5888)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable