Anti-53BP1 (C-terminal) antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

Tumor protein p53 binding protein (T153BP1) is mapped to human chromosome 15q15.3. It has methylated histone-binding module and tandem tudor domains.

免疫原

synthetic peptide corresponding to amino acids 1955-1972 of human 53BP1, conjugated to KLH via an N-terminal added cysteine residue. This sequence is conserved in mouse, and differs from rat by one amino acid

应用

Anti-53BP1 (C-terminal) antibody produced in rabbit has been used in western blotting and immunoprecipitation

生化/生理作用

Tumor protein p53 binding protein (T153BP1) has a close link to ataxia-telangiectasia mutated (ATM)-regulated events. 53BP1 becomes phosphorylated by ATM in a DNA damage-dependent manner suggesting that it participates in propagating the ATM signaling to its downstream effectors. T153BP1 also plays a key role in DNA repair by mediating nonhomologous end-joining (NHEJ) near double stranded breaks (DSBs). Fusion of T153BP1 with platelet-derived growth factor receptor beta (PDGFRβ) is implicated in a type of myeloproliferative disorder accompanied with eosinophilia.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号

MFCD09039188

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	200
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	antigen 345 kDa
species reactivity	mouse (predicted), rat (predicted), human
浓度	~1 mg/mL
technique(s)	immunoprecipitation (IP): 5-10 μg using HEK 293-T cell lysates microarray: suitable western blot: 2-4 μg/mL using U2OS total cell extracts
UniProt登记号	Q12888
运输	dry ice
储存温度	?20℃
Gene Information	human ... TP53BP1(7158) mouse ... Trp53bp1(27223) rat ... Tp53bp1(296099)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	nwg
闪点(F)	Not applicable
闪点(C)	Not applicable