Anti-Potassium Channel KCNQ5 Antibody

半岛bd体育手机客户端 说明

一般描述

KCNQ5 is subunit one of a voltage gated potassium channel expressed in the brain and other tissues. KCNQ5 forms the complete channel with KCNQ3. This channel gives rise to the "M" potassium current which is a slowly activating and deactivating current. This current plays a critical role in determining the subthreshold electrical excitability of neurons. KCNQ5 is strongly expressed in the brain but also in skeletal muscle and vascular smooth muscle cells. KCNQ5 activity is also regulated via phosphorylation by PKC and that kinase regulation may be a key to regulating excitability in neurons and muscle cells.

特异性

Western Blotting Analysis was tested on overxpressing transfected cell lysate.

免疫原

KLH-conjugated linear peptide corresponding to the Human Potassium Channel KCNQ5.

应用

This Anti-Potassium Channel KCNQ5 Antibody is validated for use in Immunohistochemistry and Western Blotting for the detection of Potassium Channel KCNQ5.
Research Category
Neuroscience
Western Blotting Analysis: A 0.1?g/mL dilution from a representative lot detected Potassium Channel KCNQ5 in 10 ?g of transient over-expression of Potassium Channel KCNQ5 in HEK293 cell lysate.

质量

Evaluated by Immunohistochemistry in human cerebral cortex tissue.
Imunnohistochemistry Analysis: A 1:2,000 dilution of this antibody detected Potassium Channel KCNQ5 in human cerebral cortex tissue.

目标描述

~103 kDa observed. Predicted to cross react to Isoforms 1, 2, and 3. Additional bands are detected in endogenous lysates.

联系

Replaces: AB5599

外形

Purified rabbit Polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	human, rat
species reactivity (predicted by homology)	canine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), giant panda (based on 100% sequence homology), feline (based on 100% sequence homology)
technique(s)	immunohistochemistry: suitable western blot: suitable
NCBI登记号	NP_062816
UniProt登记号	Q9NR82
运输	wet ice

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable