半岛bd体育手机客户端 说明

一般描述

Phosphodiesterase 4D3 (PDE4D3) is a member of the PDE cyclic nucleotides. PDE4D3 is known to be regulated by protein kinase C (PKC)-Raf-MEK-ERK and also by cAMP in vascular smooth muscle cells. PDE4D3 is a direct target of the MSH/cAMP/MITF pathway and may play a role in melanocyte differentiation. PDE4D3 is essential to have equilibrium in relaxing and contracting cues to airway smooth muscle. Down-regulation of PDE4D3 may be associated with analgesic and anti-inflammatory effects. PDE4D3 has also been linked to the risk of stroke, and in particular to polygenic stroke.

特异性

This antibody recognizes PDE4D3 at the N-terminus.

免疫原

KLH-conjugated linear peptide corresponding to the N-terminus of human PDE4D3.
Epitope: N-terminus

应用

Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience
This Anti-PDE4D3 Antibody is validated for use in WB for the detection of PDE4D3.

质量

Evaluated by Western Blot in mouse brain membrane tissue lysate.
Western Blot Analysis: 1 ?g/mL of this antibody detected PDE4D3 on 10 ?g of mouse brain membrane tissue lysate.

目标描述

~95 kDa observed. UniProt describes 12 isoforms produced by alternative splicing.

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Mouse brain membrane tissue lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	rhesus macaque, mouse, rat
species reactivity (predicted by homology)	rhesus monkey (based on 100% sequence homology), human (immunogen homology)
technique(s)	western blot: suitable
NCBI登记号	NP_006194
UniProt登记号	Q08499
运输	wet ice
Gene Information	human ... PDE4D(5144)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable