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Anti-FXR2 antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
F1554
规格纯度
clone A42, purified from hybridoma cell culture
价格
4731.57 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-FXR2 antibody, Mouse monoclonal
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Monoclonal Anti-FXR2 (mouse IgG1 isotype) is derived from the hybridoma A42 produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with human Fragile X mental retardation syndrome-related protein 2 (FXR2) recombinant protein. FXR2 gene is located on human chromosome 17 and its protein is localized mainly in the cytoplasm. FXR2 is expressed along with other proteins in the cytoplasm of neurons. It is characterized with two KH domains and one RGG box that together with fragile X mental retardation 1 (FMR1) bind to RNA. FXR2 is highly expressed in brain and testis.

特异性

Monoclonal Anti-FXR2 recognizes human, monkey, bovine, canine, rat, hamster, and mouse, FXR2, ~74 kDa, and does not crossreact with FMR or FXR1.

免疫原

human FXR2 recombinant protein.

应用

Anti-FXR2 antibody, Mouse monoclonal may be used in:

  • immunoblotting
  • immunoprecipitation
  • immunocytochemistry
  • immunohistochemistry
  • co-immunoprecipitation
  • immunofluorescence
  • sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE)

生化/生理作用

Fragile X mental retardation syndrome-related protein 2 (FXR2) knockout mice are hyperactive in the open-field test, impaired on the rotarod test, have reduced levels of prepulse inhibition, display less contextual conditioned fear, are impaired at locating the hidden platform in the Morris water task, and less sensitive to heat stimulus.
Fragile X mental retardation syndrome-related protein 2 (FXR2) is capable of forming heteromers with the others and can also form homomers. It has an independent function in tissues during embryonic development and adult life.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

储存及稳定性

For continuous use, store at 2–8 ℃ for up to one month. For prolonged storage, freeze in working aliquots. Repeated freezing and thawing, or storage in frost-free freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD02262924
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
偶联物 unconjugated
抗体形式 purified from hybridoma cell culture
antibody product type primary antibodies
克隆 A42, monoclonal
形式 buffered aqueous solution
分子量 antigen ~74 kDa
species reactivity human
technique(s) immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 2-4 μg/mL using total cell extract of HEK 293T cells
同位素/亚型 IgG1
UniProt登记号 P51116
运输 dry ice
储存温度 ?20℃
Gene Information human ... FXR2(9513)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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