Anti-CPEB1 Antibody

半岛bd体育手机客户端 说明

一般描述

Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1, CPEB1) is an RNA binding protein that contains an RNA-recognition motif and a zinc finger-containing region and is found in a wide range of vertebrates and invertebrates. CPEB1 forms the nucleus of a complex of factors that regulate poly(A) elongation and promotes polyadenylation-induced translation. CPEB1 mediates many diverse biological processes such as germ cell development, cell division and senescence, and synaptic plasticity. Recently, it was discovered that CPEB1 is involved in beta-catenin mRNA translation and cell migration in astrocytes as well as regulating hypoxia-inducible factor (HIF)-1 expression, demonstrating the wide range of processes in which CPEB1 plays a role. At least four isoforms of CPEB1 are known to exist.

特异性

This antibody recognizes the N-terminus of CPEB1.

免疫原

Epitope: N-terminus
KLH-conjugated linear peptide corresponding to the N-terminus of human CPEB1.

应用

Detect Cytoplasmic polyadenylation element-binding protein 1 using this rabbit polyclonal antibody, Anti-CPEB1 Antibody validated for use in western blotting.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
RNA Metabolism & Binding Proteins

质量

Evaluated by Western Blotting in rat brain tissue lysate.
Western Blotting Analysis: 2 ?g/mL of this antibody detected CPEB1 in 15 ?g of rat brain tissue lysate.

目标描述

~65 kDa observed. Uniprot describes 2 isoforms at ~54 kDa, one isoform at ~62 kDa, and one isoform at ~63 kDa Uncharacterized bands may appear in some lysates.

外形

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Rat brain tissue lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	rat
species reactivity (predicted by homology)	human (immunogen homology)
technique(s)	western blot: suitable
UniProt登记号	Q9BZB8
运输	wet ice
Gene Information	human ... CPEB1(64506)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable