Interferon-αA/D human

半岛bd体育手机客户端 说明

应用

Interferon-αA/D human has been used:

• for identification of coronavirus replicase inhibitors
• in combination with ACH-806 [1-(4-pentyloxy-3-trifluoromethylphenyl)-3-(pyridine-3-carbonyl)thiourea] to study the effect on hepatitis C virus (HCV) replication
• in combination with vitamin D to check reduction in HCV protein production in cell culture

生化/生理作用

Interferon-αA/D (Bg/II), also known as Universal Type I Interferon, is an α interferon hybrid that crosses the species barrier. The Bg/II denotes the restriction enzyme site from which this hybrid is constructed from recombinant human interferons αA and αD. Interferon-αA/D has been proven to be active on many mammalian cells. It can substitute for human, monkey, mouse, bovine, rat, cat, dog, rabbit, sheep, goat, horse, pig or hamster type I interferon (α, β, ω and τ). Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes), and ruminant embryos (τ subtypes). This cytokine has anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.

外形

Solution in phosphate buffered saline containing 0.1% bovine serum albumin

分析说明

The biological activity is determined in the cytopathic effect inhibition assay using MDBK cells with vesicular stomatitis virus (VSV). A cytopathic effect of 50% is produced with 1 unit/ml interferon. The units are determined with respect to NIH international standard reference for human interferonαA.

基本信息

MDL编号	MFCD01635116
NACRES	NA.32

半岛bd体育手机客户端 性质

质量水平	200
生物来源	human
重组	expressed inE. coli
测定	≥95%
形式	buffered aqueous solution
分子量	19 kDa
包装	pkg of 100K units
technique(s)	cell culture | mammalian: suitable
杂质	endotoxin, tested
颜色	colorless
UniProt登记号	P01563
运输	dry ice
储存温度	?70℃
Gene Information	human ... IFNA2(3440)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves