Anti-Calcineurin pan A Antibody

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一般描述

Calcineurin is a serine/threonine protein phosphatase involved in the mediation of signal tranduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin′s multifunctional capabilities in the regulation of calcium signaling.

特异性

This antibody recognizes both the Aα and Aβ, the major catalytic subunit gene isoforms of calcineurin in most tissues; may also react with the testis form, Aγ. This antibody has very high sensitivity and specificity, which allow detection of calcineurin in tissues where expression is low, such as lymphoid tissue. Reacts with calcineurin of all mammalian species.

免疫原

KLH-conjugated synthetic peptide corresponding to Calcineurin.

应用

Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
Research Category
Signaling
Detect Calcineurin pan A using this Anti-Calcineurin pan A Antibody validated for use in WB.

质量

Evaluated by Western Blot in Mouse brain lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Calcineurin on 10 ?g of mouse brain lysate.

目标描述

~58 kDa

联系

Replaces: AB1695

外形

Affinity purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 40% gylerol. Contains no preservative.

储存及稳定性

Store at -20°C for up to 12 months in undiluted aliquots; at this temperature the solution will
remain unfrozen.

分析说明

Control
Mouse brain lysate

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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