半岛bd体育手机客户端 说明

一般描述

2′-Deoxycytidine (deoxyC) is one of the deoxynucleosides containing cytosine as the nucleobase. It is found in the blood, feces, and urine.

应用

2′-Deoxycytidine has been used:

• as a substrate forTrypanosoma bruceicytidine deaminase (TbCDA) to measure its activity
• as a standard in the isolation and quantification of metabolite levels in murine tumor interstitial fluid by liquid chromatography-mass spectrometry (LC–MS)
• to study the role of autophagy in response to oncogenes and DNA replication stress

包装

1, 5 g in poly bottle
100, 250, 500 mg in poly bottle

生化/生理作用

2′-Deoxycytidine (deoxyC) forms dCTP upon phosphorylation which is used to synthesis DNA via various DNA polymerases or reverse transcriptases. DeoxyC is the substrate for deoxycytidine deaminase (EC 3.5.4.14) which converts it into 2′-deoxyuridine. DeoxyC is phosphorylated to the nucleotide dCMP by the enzyme deoxycytidine kinase (DCK). DeoxyC serves as a potential head and neck cancer marker.

基本信息

经验(实验)分子式	C9H13N3O4
分子量	227.22
Beilstein	87567
EC 号	213-454-1
MDL编号	MFCD00006547
PubChem化学物质编号	24893793
NACRES	NA.51

半岛bd体育手机客户端 性质

质量水平	200
生物来源	synthetic (organic)
测定	≥99% (HPLC)
形式	powder
溶解性	water: 50 mg/mL, clear, colorless to very faintly yellow
储存温度	?20℃
SMILES string	NC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](CO)O2
InChI	1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1
InChI key	CKTSBUTUHBMZGZ-SHYZEUOFSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)