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位置: 首页> 品牌> Sigma-Aldrich> 细胞松弛素B 来源于Drechslera dematioidea

Cytochalasin B fromDrechslera dematioidea

细胞松弛素B 来源于Drechslera dematioidea

品牌
Sigma-Aldrich
CAS
14930-96-2
货号
C6762
规格纯度
≥98% (HPLC), powder
价格
579.7 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
14930-96-2
Cytochalasin B from Drechslera dematioidea
Phomin
细胞松弛素B 来源于 Drechslera dematioidea
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Cytochalasin B is a cell-permeable fungal toxin / mycotoxin that binds to the ′barbed′ end of actin / actin filaments. This binding leads to:

  • Disruption of actin filaments and of interaction of actin filaments in solution
  • Inhibition of actin polymerization
  • Inhibition of subunit association and dissociation
Cytochalasin B is widely used in studies of glucose transporters (GLUT). Cytochalasin B is also used as an integral part of various in vitro micronucleus assay protocols.

包装

1, 5, 10, 25, 50 mg in serum bottle

生化/生理作用

Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.
One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin, and in studies on cytokinesis. Probe for the two hexose-transport systems in rat L6 myoblasts.

基本信息

经验(实验)分子式 C29H37NO5
分子量 479.61
Beilstein 1096207
EC 号 239-000-2
MDL编号 MFCD00077704
PubChem化学物质编号 24892890
NACRES NA.32

半岛bd体育手机客户端 性质

质量水平 300
测定 ≥98% (HPLC)
形式 powder
颜色 white
溶解性 DMSO: 10 mg/mL
作用机制 DNA synthesis | interferes
抗生素抗菌谱 fungi
储存温度 ?20℃
SMILES string C[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
InChI 1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
InChI key GBOGMAARMMDZGR-TYHYBEHESA-N

安全信息

象形图 GHS06GHS08
警示用语: Danger
危险声明 H300 + H310 + H330 - H361
预防措施声明 P201 - P202 - P260 - P280 - P302 + P352 + P310 - P304 + P340 + P310
危险分类 Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Repr. 2
储存分类代码 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK WGK 3
个人防护装备 Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Sigma-Aldrich

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