半岛bd体育手机客户端 说明
一般描述
5,5-Diphenylhydantoin sodium salt is a derivative of phenytoin. 5,5-Diphenylhydantoin is used for treating epilepsy and has antiepileptic activity. It functions by blocking the sodium channels and modulates excitation of neurons. However, the side effects include hypertrichosis and overgrowth of gum tissue around the teeth. It promotes proliferation of the neural stem cells by modulating growth factors. Diphenylhydantoin is toxic and induces apoptosis in cultured cerebellar granule neurons.
应用
5,5-Diphenylhydantoin sodium salt has been used:
生化/生理作用
减少癫痫大发作的发生率；可能通过 Na+、K+和 Ca2+通道的影响而稳定可兴奋膜。
特点和优势
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基本信息
| 线性分子式 | C15H11N2O2Na |
| 分子量 | 274.25 |
| EC 号 | 211-148-2 |
| MDL编号 | MFCD00069674 |
| PubChem化学物质编号 | 24277707 |
| NACRES | NA.77 |
半岛bd体育手机客户端 性质
| 质量水平 | 200 |
| 测定 | ≥99% |
| 溶解性 | aqueous base: soluble |
| SMILES string | [Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3 |
| InChI | 1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1 |
| InChI key | FJPYVLNWWICYDW-UHFFFAOYSA-M |
| Gene Information | human ... CNR1(1268), CNR2(1269), CYP2C9(1559), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335) rat ... Faah(29347), Scn1a(81574), Scnn1g(24768), Slc6a1(79212) |
安全信息
| 象形图 |   |
| 警示用语： | Warning |
| 危险声明 | H302 - H317 - H361 |
| 预防措施声明 | P201 - P202 - P280 - P301 + P312 - P302 + P352 - P308 + P313 |
| 危险分类 | Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
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