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Lovastatin-CAS 75330-75-5-Calbiochem

品牌
Sigma-Aldrich
CAS
75330-75-5
货号
438185
规格纯度
Lovastatin, CAS 75330-75-5, is an anti-hypercholesterolemic agent that inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.
价格
2377.87 *本价格含增值税费
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半岛bd体育手机客户端 名称:
75330-75-5
Lovastatin-CAS 75330-75-5-Calbiochem
Mevinolin, MK-803, L-Type Calcium Channel Blocker IV
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

An anti-hypercholesterolemic agent that inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Has been shown to block a series of biological events including: the activation of p21rasby insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes; the farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin); and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1phase through inhibition of proteasome. Has recently been shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and to block the transcription of type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF. This product requires activation for use in cell synchronization studies and in cell-free assay systems for HMG-CoA studies.
An anti-hypercholesterolemic agent and an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase that blocks a series of biological events including: activation of p21ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF. This product requires activation for use in cell synchronization studies and in cell-free assay systems for HMG-CoA studies.

包装

25 mg in Plastic ampoule

生化/生理作用

Product does not compete with ATP.
Reversible: no
Primary Target
Activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
Cell permeable: no

警告

Toxicity: Carcinogenic / Teratogenic (D)

重悬

Following reconstitution aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions, in high quality DMSO or ethanol are stable for up to 1 month at -20°C.

其他说明

Rao, S., et al. 1999.Proc. Natl. Acad. Sci. USA96,7197.
Carel, K., et al. 1996.J. Biol. Chem.271,30625.
McGuire, T.F., et al. 1996.J. Biol. Chem.271,27402.
Umetani, N., et al. 1996.Biochim. Biophys. Acta1303,199.
Xu, X.Q., et al. 1996.Arch. Biochem. Biophys.326,233.
Reusch, J.E.-B., et al. 1995.J. Biol. Chem.270,2036.
Jakobisiak, M., et al. 1991.Proc. Natl. Acad.Sci. USA88,3628.
Keyomarsi, K., et al. 1991.Cancer Res.51,3602.
Mendola, C.E., and Backer, J.M. 1990.Cell Growth Differ.1,499.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C24H36O5
分子量 404.54
MDL编号 MFCD00072164
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 200
测定 ≥95% (HPLC)
形式 powder
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 white to off-white
溶解性 ethanol: 25 mg/mL
DMSO: 50 mg/mL
运输 ambient
储存温度 2-8℃
InChI 1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
InChI key PCZOHLXUXFIOCF-BXMDZJJMSA-N

安全信息

象形图 GHS08
警示用语: Warning
危险声明 H351 - H361f
预防措施声明 P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类 Carc. 2 - Repr. 2
储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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