半岛bd体育手机客户端 说明

一般描述

4′-(Methylthio)acetophenone (4-(Methylthio)acetophenone,p-(methylthio) acetophenone, 4-MTAP) is a sulphur containing organic building block. It is a key intermediate in drug synthesis. Its industrial preparation, via Friedel-Crafts acylation reaction in the presence of aluminium chloride as catalyst and acetyl chloride as acylating agent has been reported. It has been prepared by the acetylation reaction of thioanisole with acetic anhydride in the presence of solid acid catalyst.

应用

4′-(Methylthio)acetophenone may be used for the synthesis of Vioxx (Rofecoxib), an non-steroidal anti-inflammatory drug (NSAID). It may be used in the synthesis of (E)-1-[4-(methylsulfanyl)phenyl]-3-phenylprop-2-en-1-one.

包装

1 g in glass bottle

基本信息

线性分子式	CH3SC6H4COCH3
分子量	166.24
EC 号	217-213-1
MDL编号	MFCD00039835
PubChem化学物质编号	24864677
NACRES	NA.22

半岛bd体育手机客户端 性质

质量水平	100
测定	97%
mp	80-82 ℃ (lit.)
SMILES string	CSc1ccc(cc1)C(C)=O
InChI	1S/C9H10OS/c1-7(10)8-3-5-9(11-2)6-4-8/h3-6H,1-2H3
InChI key	JECUZQLBQKNEMW-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves