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位置: 首页> 品牌> Sigma-Aldrich> Nucleophosmin (hNPM) human

Nucleophosmin (hNPM) human

品牌
Sigma-Aldrich
货号
SRP6281
规格纯度
recombinant, expressed inE. coli, ≥95% (SDS-PAGE)
价格
3896.85 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Nucleophosmin (hNPM) human
NPM
Numatrin
NPM1
Nucleolar phosphoprotein B23
Nucleolar protein NO38
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Nucleophosmin is a nucleus protein which belongs to the nucleoplasmin family. It is a nucleolar phosphoprotein that shuttles between the nucleus and cytoplasm during the cell cycle. Nucleophosmin / NPM1 is involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors TP53 / p53 and ARF. Subcellular localization of Nucleophosmin / NPM1 appears to be strongly correlated with NPM1 functions and cell proliferation. It is phosphorylated mainly at its central acidic domain by several upstream kinases, and its phosphorylation appears to be involved in regulating its functions in ribosome biogenesis and centrosome duplication. Nucleophosmin / NPM1 binds ribosome presumably to drive ribosome nuclear export. It is associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Nucleophosmin / NPM1 acts as a chaperonin for the core histones H3, H2B and H4. Nucleophosmin / NPM1 may act as a licensing factor to maintain proper centrosome duplication and that the Ran/CRM1 nucleocytoplasmic complex regulates local trafficking of Nucleophosmin / NPM1 to centrosomes by interacting through its nuclear export sequence motif. The recombinant protein includes NPM (292 aa) with N-terminal GST-tag.

外形

2.0 mg/mL solution in 25 mM Tris (pH 8.0) buffer containing 20% glycerol.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥95% (SDS-PAGE)
形式 liquid
分子量 59.8 kDa (292 aa + NT GST-tag)
包装 pkg of 1 mg
pkg of 100 μg
pkg of 20 μg
浓度 2 mg/mL
UniProt登记号 P06748
运输 dry ice
储存温度 ?70℃
Gene Information human ... NPM(4869)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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