MIF Antagonist, ISO-1-CAS 478336-92-4-Calbiochem

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一般描述

A cell-permeable isoxazoline compound that displays anti-inflammatory properties. Inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC₅₀= 7 ?M for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE₂and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages. Shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model.
A cell-permeable isoxazoline compound that displays anti-inflammatory properties. Inhibits MIF tautomerase activity by binding to its catalytic active site (IC₅₀= 7 ?M for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE₂and COX-2 in human monocytes, and arachidonic acid in RAW 264.7 macrophages. Shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model. Also available as a 50 mM solution in DMSO (Cat. No. 505225).

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
MIF tautomerize
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 7 ?M for D-dopachrome tautomerase

警告

Toxicity: Standard Handling (A)

重悬

Following reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Cvetkovic, I., et al. 2005.Endocrinology,146,2942.
Lubetsky, J.B., et al. 2002.J. Biol. Chem.277,24976.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

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