A922500

半岛bd体育手机客户端 说明

应用

A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages.

包装

1, 5, 10 mg in glass bottle

生化/生理作用

The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease.
Diacylglycerol acyltransferase (DGAT-1) inhibitor; IC₅₀7 to 24 nM

外形

A922500 is supplied as a crystalline solid.

制备说明

A stock solution may be made by dissolving the A922500 in the solvent of choice. A922500 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).

基本信息

经验(实验)分子式	C26H24N2O4
分子量	428.48
NACRES	NA.77

半岛bd体育手机客户端 性质

生物来源	synthetic (organic)
质量水平	100
测定	>95% (HPLC)
形式	powder
分子量	Mw428.5
溶解性	DMSO: 10 mg/mL, clear, colorless to greenish-yellow
储存温度	?20℃
InChI key	BOZRFEQDOFSZBV-DHIUTWEWSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable