半岛bd体育手机客户端 说明

一般描述

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in caner diagnosis and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer. The recombinant protein includes hNNMT with N-terminal His-tag.

外形

2 mg/mL solution in HEPES Buffer containing 20% glycerol.

基本信息

NACRES

NA.32

半岛bd体育手机客户端 性质

重组	expressed in HEK 293 cells
测定	≥98% (SDS-PAGE)
形式	liquid
分子量	45.9 kDa (384 aa + NT 6xHis-tag)
包装	pkg of 1 mg pkg of 100 μg pkg of 20 μg
浓度	2 mg/mL
UniProt登记号	O34714
运输	dry ice
储存温度	?70℃
Gene Information	Bacillus subtilis... OxdC(938620)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable