半岛bd体育手机客户端 说明

应用

1,4-Naphthoquinone is the key structural moiety of many anticancer and antifungal agents.
It can be used to synthesize:

• 3,3-Disubstituted oxindoles via asymmetric Michael addition to oxindole.
• Bioactive isoindolines via asymmetric 1,3-dipolar cycloaddition to azomethine ylides generatedin situfrom aldehydes and diethyl aminomalonate.
• α,α-Difluoro-β-hydroxy ketone via ‘on water′ catalyst-free Mukaiyama-aldol reaction with difluoroenoxysilane.
• 2-Hydroxy-3-anilino-1,4-naphthoquinone, which shows potent in vivo antimalarial activity.

Additional appilcation include:

• As an arylation reagent for the α-arylation of aldehydes.
• As a starting material in the multi-step synthesis of benz[f]indole-4,9-diones.

基本信息

经验(实验)分子式	C10H6O2
分子量	158.15
Beilstein	878524
EC 号	204-977-6
MDL编号	MFCD00001676
PubChem化学物质编号	329762061
NACRES	NA.22

半岛bd体育手机客户端 性质

质量水平	200
等级	purum
测定	≥96.5% (HPLC)
形式	powder
mp	119-122 ℃ (lit.) 120-124 ℃
SMILES string	O=C1C=CC(=O)c2ccccc12
InChI	1S/C10H6O2/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6H
InChI key	FRASJONUBLZVQX-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301 + H311 - H314 - H317 - H330 - H335 - H410
预防措施声明	P260 - P280 - P301 + P310 + P330 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
危险分类	Acute Tox. 1 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Corr. 1C - Skin Sens. 1 - STOT SE 3
靶器官	Respiratory system
储存分类代码	6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	285.8 °F
闪点(C)	141 ℃
个人防护装备	Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges