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JAK Inhibitor I-CAS 457081-03-7-Calbiochem

品牌
Millipore
CAS
457081-03-7
货号
420099
规格纯度
JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC50= 15 nM), JAK2 (IC50= 1 nM), JAK3 (Ki= 5 nM) and Tyk2 (IC5
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2340.22 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
457081-03-7
JAK Inhibitor I-CAS 457081-03-7-Calbiochem
2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, Pyridone 6, P6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A potent, reversible, cell-permeable, and ATP-competitive inhibitor of Janus protein tyrosine kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC50= 15 nM for murine JAK1), JAK2 (IC50= 1 nM), JAK3 (Ki= 5 nM), and Tyk2 (IC50= 1 nM). Inhibits other kinases at much higher concentrations. Shown to inhibit IL2- and IL4-dependent proliferation of CTLL cells and block the phosphorylation of STAT5; and further induce growth inhibition of multiple myeloma cells expressing activated JAKs and STAT3, unlike AG 490 (Cat. No. 658401). A 10 mM (500 ?g/162 ?l) solution of JAK Inhibitor I (Cat. No. 420097) in DMSO is also available.
A potent, cell-permeable, reversible, and ATP-competitive inhibitor of Janus protein tyrosine kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC50= 15 nM for murine JAK1), JAK2 (IC50= 1 nM), JAK3 (Ki= 5 nM), and Tyk2 (IC50= 1 nM). Inhibits other kinases at much higher concentrations. Shown to inhibit IL2- and IL4-dependent proliferation of CTLL cells and block the phosphorylation of STAT5, and further induce growth inhibition of multiple myeloma cells expressing activated JAKs and STAT3, unlike AG 490 (Cat. No. 658401).

包装

500 μg in Plastic ampoule
1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Target Ki: 5 nM against JAK3
Target IC50: 15 nM against murine JAK1; 1 nM against JAK2; 1 nM against Tyk2
Reversible: yes
Cell permeable: yes
Primary Target
murine JAK1
Product competes with ATP.

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Pedranzini, L., et al. 2006.Cancer Res.66,9714.
Lucet, I.S., et al. 2005.Blood107,176.
Thompson, J.E., et al. 2002.Bioorg. Med. Chem. Lett.12,1219.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C18H16FN3O
分子量 309.34

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 off-white
溶解性 DMSO: 5 mg/mL
运输 ambient
储存温度 ?20℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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