半岛bd体育手机客户端 说明
一般描述
Fluorogenic CPP-32/apopain substrate. Also acts as a substrate for granzyme B-processed ICE-LAP3. Reaction can be monitored by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. Excitation max: ~400 nm; emission max: ~505 nm.
Fluorogenic caspase-3 substrate. Also acts as a substrate for granzyme B-processed ICE-LAP3. Reaction can be monitored by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. Also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10.
包装
1, 5 mg in Plastic ampoule
生化/生理作用
Product does not compete with ATP.
Reversible: no
Primary Target
Fluorogenic caspase-3 substrate.
Cell permeable: no
警告
Toxicity: Standard Handling (A)
序列
Z-Asp-Glu-Val-Asp-AFC
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
其他说明
Keramaris, E., et al. 2000.Mol. Cell Neurosci.15,368.
Thornberry, N.A., and Lazebnik, Y. 1998.Science281,1312.
Kluck, R.M., et al. 1997.Science275,1132.
Talanian, J., et al. 1997.J. Biol. Chem.272,9677.
Chinnaiyan, A.M., et al. 1996.Curr. Biol.6,897.
Nicholson, D.W., et al. 1995.Nature376,37.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C36H38F3N5O14 |
| 分子量 | 821.71 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze |
| 颜色 | white to off-white |
| 溶解性 | DMSO: 10 mg/mL |
| 荧光 | λex~400 nm λem~505 nm |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
