半岛bd体育手机客户端 说明
一般描述
A cell-permeable, anti-microbial xanthone orignally isolated from the gamboge resin ofGarcinia hanburyi. Acts as a caspase activator and apoptosis inducer. Shown to inhibit the growth of HeLa and HEL cells (MIC = 12.5 ?g/ml). Reported to block telomerase activity in SMMC-7721 cells. Shown to induce tyrosine kinase phosphatase SHP-1 and suppress Stat3 activation.
A cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties. Shown to inhibit the growth of HeLa and HEL cells minimal inhibitory concentrations (MIC = 12.5 ?g/ml).
包装
25 mg in Alu drum
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
Caspase activator and an apoptosis inducer
MIC = 12.5 ?g/ml in inhibiting the growth of HeLa and HEL cells
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Toxic & Carcinogenic / Teratogenic (G)
其他说明
Prasad, S., et al. 2011.Cancer Prev. Res.4,1084.
Guo, Q.L., et al. 2004.Acta Pharmacol. Sin.25,769.
Asano, J., et al. 1996.Phytochemistry41,815.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C38H44O8 |
| 分子量 | 628.75 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (TLC) |
| 形式 | amorphous solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | orange |
| 溶解性 | DMSO: 10 mg/mL ethanol: soluble |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| InChI | 1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23?,27?,36-,37?,38-/m1/s1 |
| InChI key | GEZHEQNLKAOMCA-PLUQQRNKSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H301 - H315 - H319 - H335 |
| 预防措施声明 | P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
