半岛bd体育手机客户端 说明

一般描述

An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. It has been shown to be an effective agent in prevention of chemically-induced mammary tumors in rats. It also inhibits the phase I cytochrome P450 isoenzymes 2E1 and IA2 which have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by mitogen-activated protein kinase (MAPK) pathway.
An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. Shown to be an effective agent in prevention of chemically-induce mammary tumors in rats. Also shown to inhibit the phase I cytochrome P450 isoenzymes 2E1 and IA2 that have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by the mitogen-activated protein kinase (MAPK) pathway.

包装

25 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze DMSO stock solutions (-20°C) and ethanol stock solutions (-70°C). DMSO stock solutions are stable for up to 3 months at -20°C and ethanol stock solutions are stable for up to 3 months at -70°C.

其他说明

Gamet-Payrastre, L., et al. 2000.Cancer Res.60,1426.
Yu, R., et al. 2000.J. Biol. Chem.275,2322.
Yu, R., et al. 1999.J. Biol. Chem.274,27545.
Barcelo, S., et al. 1998.Mutat. Res.402,111.
Maheo, K., et al. 1997.Cancer Res.57,3649.
Zhang, Y., et al. 1994.Proc. Natl. Acad. Sci. USA91,3147.
Zhang, Y., et al. 1992.Proc. Natl. Acad. Sci. USA89,2399.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C6H11NOS2
分子量	177.29
MDL编号	MFCD00198068
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (UPLC)
形式	liquid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	slight yellow
溶解性	ethanol: 10 mg/mL DMSO: 20 mg/mL
运输	ambient
储存温度	?20℃
InChI	1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
InChI key	SUVMJBTUFCVSAD-UHFFFAOYSA-N

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 3