半岛bd体育手机客户端 说明
一般描述
Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate,Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na+channel activator that causes contractile paralysis in animal models. The excitatory action on nerve and muscle membranes is responsible for a wide spectrum of toxic effects, including massive transmitter release from nerve endings, muscle fasiculation, and ventricular fibrillation. The excitatory action is due to opening of the Na+channels. The toxin does not bind either to the TTX or to the aconitine/veratridine sites.
Lipid-soluble polyether neurotoxin that binds to Na+channels on nerves and muscles causing an excessive influx of Na+across membranes. Binds at site 5 on the voltage-sensitive Na+channel.
包装
100 μg in Glass bottle
yes
Packaged under inert gas
生化/生理作用
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Neurotoxin that binds to Na+ channels on nerves and muscles.
警告
Toxicity: Highly Toxic (H)
重悬
Following reconstitution, aliquot, purge with iniert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
From Catalog:
Solubitlity- removed acetone, EtOAc
其他说明
Edwards, R.A., et al. 1992.Mol. Brain Res.14,64.
Trainer, V.L. 1991.Mol. Pharmacol.40,988.
Tsai, M.C., and Chen, M.L. 1991.Br. J. Pharmacol.103,1126.
Trainer, V.L., et al. 1990.ACS Symposium Series418,166.
Baden, G. 1989.FASEB J.3,1807.
Baden, D.G., et al. 1988.Toxicon26,97.
Poli, M.A., et al. 1986.Mol. Pharmacol.30,129.
Shimizu, Y., et al. 1986.J. Am. Chem. Soc.108,514.
Nakanishi, K. 1985.Toxicon23,473.
Baden, D.G., et al. 1982.Toxicon19,455.
Catterfall, W.A., and Risk, M. 1981.Mol. Pharmacol.19,345.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C50H70O14 |
| 分子量 | 895.08 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze |
| 颜色 | tan to white |
| 溶解性 | ethyl acetate: soluble methanol: soluble water: soluble |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
| InChI | 1S/C50H70O14/c1-25(24-51)14-28-17-37(52)50(8)41(54-28)19-33-34(61-50)18-32-29(55-33)10-9-12-46(4)42(58-32)23-49(7)40(62-46)21-39-47(5,64-49)13-11-30-44(60-39)26(2)15-31-36(56-30)22-48(6)38(57-31)20-35-45(63-48)27(3)16-43(53)59-35/h9-10,16,24,26,28-42,44-45,52H,1,11-15,17-23H2,2-8H3/b10-9- |
| InChI key | LYTCVQQGCSNFJU-KTKRTIGZSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H300 + H310 + H330 |
| 预防措施声明 | P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310 |
| 危险分类 | Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral |
| 储存分类代码 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
