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2-Chlorotrityl chloride, polymer-bound

聚合物键合型 2-氯代三苯甲基氯

品牌
Sigma-Aldrich
CAS
42074-68-0
货号
532282
规格纯度
200-400 mesh, extent of labeling: 0.3-0.8 mmol/g Cl loading, 2 % cross-linked
价格
2795.93 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
42074-68-0
2-Chlorotrityl chloride, polymer-bound
2,α-Dichlorobenzhydryl-polystyrene crosslinked with divinylbenzene
聚合物键合型 2-氯代三苯甲基氯
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

  • Acid labile resin used in Fmoc-based solid phase peptide synthesis.
  • Mild acidic cleavage conditions lead to the release of the peptide acid where fully protected peptides can be released if desired.
  • 2-Chlorotrityl chloride resins prevent racemization of the first amino acid and are thus very useful when racemic mixtures are forming (common with residues such as His or Cys).
  • This resin also prevents diketopiperazide formation, which can be an issue with proline C-terminal peptide sequences.

Use:
  • Attachment of the first amino acid residue is effected by stirring the resin, the protected amino acid, and excess diisopropylethylamine (DIEA) in dichloromethane.
  • Cleavage of the final protected peptide fragment is achieved under very mild conditions using either acetic acid/trifluoroethanol (TFE)/dichloromethane (1:1:8; v/v/v), hexafluoroisopropanol (HFIP)/dichloromethane (1:4; v/v) or simply 0.5% trifluoroacetic acid/dichloromethane (v/v).
  • Higher concentrations of TFA can be used if retention of peptide side chaing protecting groups is unimportant. Note that trityl chloride is moisture-sensitive, and, therefore, should be stored and handled appropriately.
  • If the resin becomes deactivated, treatment with acetyl chloride or SOCl2in toluene before use is recommended to restore its activity.

包装

5 g in glass bottle

基本信息

Beilstein 1983914
MDL编号 MFCD00040399
PubChem化学物质编号 24877874
NACRES NA.22

半岛bd体育手机客户端 性质

质量水平 100
交联 2 % cross-linked
reaction suitability reaction type: Fmoc solid-phase peptide synthesis
标记范围 0.3-0.8 mmol/g Cl loading
粒径 200-400 mesh
application(s) peptide synthesis
SMILES string Clc1ccccc1C(Cl)(c2ccccc2)c3ccccc3
InChI 1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H
InChI key JFLSOKIMYBSASW-UHFFFAOYSA-N

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H315 - H319 - H335
预防措施声明 P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类 Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官 Respiratory system
储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

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