半岛bd体育手机客户端 名称：
42074-68-0
2-Chlorotrityl chloride, polymer-bound
2,α-Dichlorobenzhydryl-polystyrene crosslinked with divinylbenzene
聚合物键合型 2-氯代三苯甲基氯
半岛bd体育手机客户端 介绍：
半岛bd体育手机客户端 说明
应用
- Acid labile resin used in Fmoc-based solid phase peptide synthesis.
- Mild acidic cleavage conditions lead to the release of the peptide acid where fully protected peptides can be released if desired.
- 2-Chlorotrityl chloride resins prevent racemization of the first amino acid and are thus very useful when racemic mixtures are forming (common with residues such as His or Cys).
- This resin also prevents diketopiperazide formation, which can be an issue with proline C-terminal peptide sequences.
Use:
- Attachment of the first amino acid residue is effected by stirring the resin, the protected amino acid, and excess diisopropylethylamine (DIEA) in dichloromethane.
- Cleavage of the final protected peptide fragment is achieved under very mild conditions using either acetic acid/trifluoroethanol (TFE)/dichloromethane (1:1:8; v/v/v), hexafluoroisopropanol (HFIP)/dichloromethane (1:4; v/v) or simply 0.5% trifluoroacetic acid/dichloromethane (v/v).
- Higher concentrations of TFA can be used if retention of peptide side chaing protecting groups is unimportant. Note that trityl chloride is moisture-sensitive, and, therefore, should be stored and handled appropriately.
- If the resin becomes deactivated, treatment with acetyl chloride or SOCl2in toluene before use is recommended to restore its activity.
包装
1, 5 g in glass bottle
基本信息
| Beilstein |
1983914 |
| MDL编号 |
MFCD00040399 |
| PubChem化学物质编号 |
24877876 |
半岛bd体育手机客户端 性质
| 质量水平 |
100 |
| 交联 |
1 % cross-linked |
| reaction suitability |
reaction type: Fmoc solid-phase peptide synthesis |
| 标记范围 |
1.0-1.5 mmol/g Cl loading |
| 粒径 |
200-400 mesh |
| application(s) |
peptide synthesis |
| SMILES string |
Clc1ccccc1C(Cl)(c2ccccc2)c3ccccc3 |
| InChI |
1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H |
| InChI key |
JFLSOKIMYBSASW-UHFFFAOYSA-N |
安全信息
| 象形图 |
 |
| 警示用语： |
Warning |
| 危险声明 |
H315 - H319 - H335 |
| 预防措施声明 |
P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338 |
| 危险分类 |
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 |
Respiratory system |
| 储存分类代码 |
11 - Combustible Solids |
| WGK |
WGK 3 |
| 闪点(F) |
Not applicable |
| 闪点(C) |
Not applicable |
| 个人防护装备 |
dust mask type N95 (US), Eyeshields, Gloves |
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