半岛bd体育手机客户端 说明
一般描述
A cell-permeable, irreversible endothelial nitric oxide synthase inhibitor. Inhibits iNOS in macrophages (IC50= 5 nM). Shown to inhibit acetylcholine-induced relaxation of preconstricted rat thoracic aortic rings (IC50= 180 nM). Blocks K+and Ca2+currents in arterial smooth muscle cells. Inhibitor of mitochondrial NADH-ubiquinone oxidoreductase. Inhibits other NADH utilizing flavoproteins, such as NADPH oxidase in human neutrophils and macrophages. Causes pressor and tachycardiac effects via indirect activation of the sympathetic nervous system.
A cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS). Shown to inhibit acetylcholine-induced relaxation of preconstricted rat thoracic aortic rings (IC50= 180 nM). Also inhibits iNOS in macrophages (IC50= 50 nM). Blocks K+and Ca2+currents in arterial smooth muscle cells. Inhibitor of mitochondrial NADPH-ubiquinone oxido-reductase.
包装
10 mg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Primary Target
eNOS
Product does not compete with ATP.
Reversible: no
Target IC50: 180 nM against endothelial nitric oxide synthase (eNOS)
警告
Toxicity: Carcinogenic / Teratogenic (D)
制备说明
Slight warming is required for complete solubility.
重悬
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Wang, Y.X., et al. 1995.Br. J. Pharmacol.114,194.
Majander, A., et al. 1994.J. Biol. Chem.269,21037.
Weir, E.K., et al. 1994.J. Appl. Physiol.76,2611.
Wang, Y.X., et al. 1993.Br. J. Pharmacol.110,1232.
Wang, Y.X., and Pang, C.C. 1993.Br. J. Pharmacol.109,1186.
Stuehr, D.J., et al. 1991.FASEB J.5,98.
Handcock, J.T., and Jones, O.T.G. 1987.Biochem. J.242,103.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C12H8ClI |
| 分子量 | 314.55 |
| MDL编号 | MFCD00214165 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | crystalline solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | off-white |
| 溶解性 | DMSO: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
