Clodronate, Disodium Salt-CAS 22560-50-5-Calbiochem

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一般描述

A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC₅₀= 100 nM).
A non-amino, chloro-containing, bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. Metabolized to a non-hydrolyzable ATP analog in osteoclasts and macrophages that induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion and migration of PC-3 prostate cancer cells (IC₅₀= 100 nM).

包装

10 mg in Plastic ampoule

生化/生理作用

Primary Target
Osteoclast-mediated bone resorption
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Target IC₅₀: 100 nM inhibiting invasion, adhesion, and migration of PC-3 prostate cancer cells

警告

Toxicity: Standard Handling (A)

其他说明

Lehenkari, P.P., et al. 2002.Mol. Pharmacol.61,1255.
Virtanen, S.S., et al. 2002.Cancer Res.62,2708.
Smith, R., et al. 1971.Lancet1,945.
Fleisch, H., et al. 1969.Nature223,211.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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