半岛bd体育手机客户端 说明
Amino Acid Sequence
Gly-Arg-Gly-Asp-Ser-Pro-Lys
一般描述
Gly-Arg-Gly-Asp-Ser-Pro-Lys is a RGD peptide. Naturally occurring RGD peptides, present in the ECM (extracellalar matrix) proteins, are involved in facilitating integrin-mediated cell adhesion to matrix proteins. RGD peptide is present as repeats in cell-adhesion protein, such as fibronectin and vitronectin. This tripeptide is recognized by cells by specific integrins (e.g. β1 , β3 , and β5 subunits), present on the cell surface and associated with the actin filament via the FA (focal adhesion)-complex.
应用
Gly-Arg-Gly-Asp-Ser-Pro-Lys (RGD peptide) has been used-
生化/生理作用
Fibronectin analog that binds to integrins.
基本信息
经验(实验)分子式 | C28H49N11O11 |
分子量 | 715.76 |
MDL编号 | MFCD00076462 |
PubChem化学物质编号 | 24895055 |
NACRES | NA.32 |
半岛bd体育手机客户端 性质
质量水平 | 200 |
生物来源 | human |
测定 | ≥97% (HPLC) |
形式 | powder |
technique(s) | blocking: suitable ligand binding assay: suitable |
储存温度 | ?20℃ |
SMILES string | NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CN)C(O)=O |
InChI | 1S/C28H49N11O11/c29-8-2-1-5-16(27(49)50)37-25(47)19-7-4-10-39(19)26(48)18(14-40)38-24(46)17(11-22(43)44)36-21(42)13-34-23(45)15(35-20(41)12-30)6-3-9-33-28(31)32/h15-19,40H,1-14,29-30H2,(H,34,45)(H,35,41)(H,36,42)(H,37,47)(H,38,46)(H,43,44)(H,49,50)(H4,31,32,33)/t15-,16-,17-,18-,19-/m0/s1 |
InChI key | ZRVZOBGMZWVJOS-VMXHOPILSA-N |
Gene Information | human ... ITGA2B(3674), ITGAV(3685) |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich