Z-Leu-Leu-Norvalinal

半岛bd体育手机客户端 说明

Amino Acid Sequence

Z-Leu-Leu-Nva

包装

1, 5 mg in serum bottle

生化/生理作用

Potent inhibitor of the 20S proteasome (K_i= 21 nM) and 26S proteasome (K_i= 35 nM). Cells treated with 54 μM N-CBZ-Leu-Leu-Norvalinal showed complete block of the G1/S and metaphase transitions and delayed passage through S-phase. Induces apoptosis in Rat-1 and PC12 cells, perhaps by accumulation of stabilized p53.

基本信息

经验(实验)分子式	C25H39N3O5
分子量	461.59
PubChem化学物质编号	329775129
NACRES	NA.32

半岛bd体育手机客户端 性质

质量水平	100
测定	≥90% (HPLC)
形式	powder
颜色	white
溶解性	DMSO: soluble
储存温度	?20℃
SMILES string	CCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O
InChI	1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1
InChI key	QEJRGURBLQWEOU-FKBYEOEOSA-N
Gene Information	human ... PSMA1(5682), PSMC1(5700) mouse ... PSMA1(26440), PSMC1(19179) rat ... PSMA1(29668), PSMC1(117263)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)