半岛bd体育手机客户端 说明
应用
Olefinic alpha-methyl amino acid for peptide stapling. Upon incorporation of this amino acid into a peptide, along with another of the same or derivative with a different length of the olefinic side chain, the two can be ′stapled′ via a ring closing metathesis reaction with Grubb′s catalyst (product # 579726). The resulting stapled peptide macrocycle has been shown to stabilize the alpha-helical structure of peptides, which can lead to favorable biological characteristics such as increased proteolytic stability and cellular uptake.
包装
1, 5 g in glass bottle
基本信息
经验(实验)分子式 | C26H31NO4 |
分子量 | 421.53 |
MDL编号 | MFCD12925761 |
PubChem化学物质编号 | 329799756 |
NACRES | NA.26 |
半岛bd体育手机客户端 性质
质量水平 | 200 |
形式 | solid |
reaction suitability | reaction type: Fmoc solid-phase peptide synthesis |
application(s) | peptide synthesis |
官能团 | Fmoc |
储存温度 | ?20℃ |
SMILES string | O=C(OCC1C(C=CC=C2)=C2C3=C1C=CC=C3)N[C@@](CCCCCCC=C)(C)C(O)=O |
InChI | 1S/C26H31NO4/c1-3-4-5-6-7-12-17-26(2,24(28)29)27-25(30)31-18-23-21-15-10-8-13-19(21)20-14-9-11-16-22(20)23/h3,8-11,13-16,23H,1,4-7,12,17-18H2,2H3,(H,27,30)(H,28,29)/t26-/m1/s1 |
InChI key | MADFVGMQNXRFAF-AREMUKBSSA-N |
安全信息
象形图 | |
警示用语: | Warning |
危险声明 | H400 |
预防措施声明 | P273 |
危险分类 | Aquatic Acute 1 |
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |