3D-PHAD^?

半岛bd体育手机客户端 说明

一般描述

Vaccination is well-accepted as an effective method to prevent infections by mounting pathogen-specific immune responses prior to the infection. Usually, immunization with vaccine antigens alone is not able to induce robust or long-lasting immune responses — resulting in failure of protective immunity against infections. Thus, adjuvants are required to enhance cellular or humoral immune responses upon immunization. Because vaccine adjuvants using Lipid A have proven to be safe and effective in inducing Th-1 type immune responses to heterologous proteins in animal and human vaccines, Avanti developed Phosphorylated HexaAcyl Disaccharide (PHAD^?), the first fully synthetic monophosphoryl Lipid A available for use as an adjuvant in human vaccines.

应用

3D-PHAD^?has been used:

• as a synthetic adjuvant for respiratory syncytial virus (RSV) vaccine
• as a synthetic adjuvant to prepare hepatitis B virus (HBV) and virus-like particles (VLP)-based human papillomavirus (HPV) vaccines
• in liposome preparation for the generation of army liposome formulation (ALF) for human immunodeficiency (HIV) gp140 antigen immunization studies in mice.

生化/生理作用

3-deacyl-phosphorylated hexa-acyl disaccharide (3D-PHAD^?) is derived from monophosphoryl lipid A. It is amphiphilic and associates with the virosomal membranes.

包装

2 mL Amber Glass Crimp Cap Vial (699852P-1mg)
2 mL Amber Glass Crimp Cap Vial (699852P-5mg)

其他说明

For R&D use only. Not for drug, household, or other uses.

法律信息

3D-PHAD is a registered trademark of Avanti Polar Lipids, Inc.
PHAD is a registered trademark of Avanti Polar Lipids, Inc.

基本信息

经验(实验)分子式	C82H158N3O20P
分子量	1537.11
NACRES	NA.25

半岛bd体育手机客户端 性质

测定	>99% (HPLC)
形式	powder
包装	pkg of 1 × 1 mg (699852P-1mg) pkg of 1 × 5 mg (699852P-5mg)
manufacturer/tradename	Avanti Polar Lipids 699852P
运输	dry ice
储存温度	?20℃
SMILES string	O[C@H]([C@@H](CO[C@@H]([C@@H]1NC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](CO)[C@@H](OP([O-])(O)=O)[C@@H]1OC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](O)[C@@H]2NC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H]2O.[NH4+]

安全信息

储存分类代码

13 - Non Combustible Solids