W146

半岛bd体育手机客户端 说明

一般描述

W146 is a sphingosine-1-phosphate 1 (S1P1) selective antagonist.
Compound 2a is a selective antagonist for human S1P1 (hS1P1) receptor activation by the physiological agonist S1P.

应用

W146 has been used:

• to verify the mode of action of sphingosine-1-phosphate (S1P) in human bone marrow derived mesenchymal stem cells (hMSCs ) and primary human hepatogenic profibrotic cells (hHPCs)
• to study oxidative stress and drug treatment in granulosa cells
• to evaluate its effects on transendothelial electrical resistance (TEER)

生化/生理作用

W146 acts as an orthosteric antagonist. It is linked to blood lymphopenia and lung edema in mice.

包装

5 mL Amber Glass Screw Cap Vial (857390P-10mg)
5 mL Amber Glass Screw Cap Vial (857390P-1mg)

基本信息

经验(实验)分子式	C18H28F3N2O6P
分子量	456.39
NACRES	NA.25

半岛bd体育手机客户端 性质

测定	>99% (TLC)
形式	powder
包装	pkg of 1 × 1 mg (857390P-1mg) pkg of 1 × 10 mg (857390P-10mg)
manufacturer/tradename	Avanti Polar Lipids 857390P
运输	dry ice
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	No data available
闪点(C)	No data available