半岛bd体育手机客户端 说明
包装
1, 5 mg in glass bottle
生化/生理作用
S14161 inhibits D-cyclin transactivation by inhibition of phosphoinositide 3-kinase (PI3K) activity. S14161 is a pan-class I PI3K inhibitor. S14161 inhibited the activity of all 4 isoforms of the PI3K class I family, and unlike LY294002, had little effect on class IV enzymes mechanistic target of rapamycin (mTOR) and DNA-PKcs (DNA-dependent protein kinase, catalytic subunit), or on AKT-1, -2, or -3 or PDK1. S14161 inhibited the expression of cyclins D1, D2, and D3, leading to the arrest of cells at the G0/G1 phase, and has exhibited anti-myeloma and anti-leukemia activity with no gross toxicity.
基本信息
| 经验(实验)分子式 | C17H14FNO4 |
| 分子量 | 315.30 |
| MDL编号 | MFCD00112055 |
| PubChem化学物质编号 | 329825969 |
| NACRES | NA.77 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 储存条件 | desiccated protect from light |
| 颜色 | white to beige |
| 储存温度 | ?20℃ |
| SMILES string | FC(C=C1)=CC=C1C2C([N+]([O-])=O)=CC3=CC=CC(OCC)=C3O2 |
| InChI | 1S/C17H14FNO4/c1-2-22-15-5-3-4-12-10-14(19(20)21)16(23-17(12)15)11-6-8-13(18)9-7-11/h3-10,16H,2H2,1H3 |
| InChI key | BFZXDHIUPNWOMT-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H315 |
| 危险分类 | Skin Irrit. 2 |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
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