Methyl-3,4-dephostatin

半岛bd体育手机客户端 说明

应用

Methyl-3,4-dephostatin has been used as:

• an inhibitor for methyltransferases
• a kinase-related inhibitor for human transglutaminase
• a cysteine binding compound for screening its effect on C-terminal domain (CTD) of human immunodeficiency virus (HIV-1) capsid protein

生化/生理作用

Methyl-3,4-dephostatin is a tyrphostin-related compound isolated fromStreptomycesMJ742-NF5 strain. It favors nerve growth factor-based neurite formation in pheochromocytoma PC12 cells. Being a stable analog of the nitrosoaniline dephostatin, it can mimic phosphotyrosine substrate for Tyrosyl-DNA phosphodiesterase I (TdpI).
Stable analog of dephostatin; selective protein tyrosine phosphatase 1B and SHPTP-1 inhibitor; does not inhibit CD45-associated phosphatases.

基本信息

经验(实验)分子式	C7H8N2O3
分子量	168.15
MDL编号	MFCD01076450
PubChem化学物质编号	24278575
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	>98% (HPLC)
形式	powder
颜色	red-brown
溶解性	DMSO: soluble 18 mg/mL H2O: insoluble
储存温度	2-8℃
SMILES string	CN(N=O)c1ccc(O)c(O)c1
InChI	1S/C7H8N2O3/c1-9(8-12)5-2-3-6(10)7(11)4-5/h2-4,10-11H,1H3
InChI key	XAKAQCMEMMZUEO-UHFFFAOYSA-N
Gene Information	human ... PTPN1(5770)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)