半岛bd体育手机客户端 说明

一般描述

Chemical structure: macrolide
Erythromycin is an antibiotic produced by growth of certain strains ofStreptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airwaysin vitro,and for selecting plasmid-cured and recombinantlactococcus lactisMG1363 strains.

应用

Erythromycin has been used:

• as a supplement for nutrient broth medium for culturing green fluorescent protein (GFP)- expressing E. coli
• as a model drug to determine small intestinal (SMI) microtissue viability using the MTT assay{254
• as an antibiotic to study the treatment strategies of chronic infections

包装

1, 5 g in poly bottle

生化/生理作用

作用机制: 红霉素通过在转肽步骤中抑制延伸起作用，特别是通过结合细菌70S rRNA复合物的50S亚单位来抑制氨酰从A位点到P位点的易位。
抗菌谱：该半岛bd体育手机客户端 可以抗革兰氏阴性和革兰氏阳性细菌。

注意

This product is stable in solution at 37℃ for 3 days. Stock solutions should be stored at 2-8℃.

制备说明

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

基本信息

经验(实验)分子式	C37H67NO13
分子量	733.93
Beilstein	75279
EC 号	204-040-1
MDL编号	MFCD00084654
PubChem化学物质编号	24894612
NACRES	NA.76

半岛bd体育手机客户端 性质

质量水平	200
半岛bd体育手机客户端 线	BioReagent
形式	powder
效能	≥850 μg per mg
technique(s)	cell culture | mammalian: suitable
杂质	≤0.1 EU/mg endotoxin
颜色	white
mp	133 ℃
溶解性	2 M HCl: 50 mg/mL (Stock solutions should be stored at 2-8 ℃. Stable at 37 ℃ for 3 days.) ethanol: soluble (Stock solutions should be stored at 2-8 ℃. Stable at 37 ℃ for 3 days.)
抗生素抗菌谱	Gram-negative bacteria Gram-positive bacteria
作用机制	protein synthesis | interferes
SMILES string	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
InChI	1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
InChI key	ULGZDMOVFRHVEP-RWJQBGPGSA-N
Gene Information	human ... ABCB1(5243), CYP3A4(1576), MLNR(2862) mouse ... Abcb1a(18671), Abcb1b(18669)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)