(S)-AMPA

半岛bd体育手机客户端 说明

一般描述

AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) activates excitatory postsynaptic currents (EPSC).

应用

(S)-AMPA has also been used to activate rostromedial tegmental nucleus (RMTg), to study aversive conditioning in relation with cocaine-induced avoidance behaviors in mice.
(S)-AMPA has been used to selectively eliminate the neural cochlear component of adult barn owls by destroying afferent synapses.

生化/生理作用

Active enantiomer of (RS)-AMPA zwitterion. Potent agonist at the AMPA subclass of ionotropic glutamate receptors.

特点和优势

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This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C7H10N2O4
分子量	186.17
MDL编号	MFCD00672630
PubChem化学物质编号	24890421
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98%
SMILES string	Cc1onc(O)c1C[C@H](N)C(O)=O
InChI	1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
InChI key	UUDAMDVQRQNNHZ-YFKPBYRVSA-N
Gene Information	human ... GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK1(2897) mouse ... Gria1(14799) rat ... Gria1(50592), Gria2(29627), Gria3(29628), Gria4(29629), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grin2b(24410), Grm6(24419)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)