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Hypothemycin

品牌
Sigma-Aldrich
CAS
76958-67-3
货号
H1667
规格纯度
fromHypomyces trichothecoides, ≥98% (HPLC)
价格
2081.79 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
76958-67-3
Hypothemycin
3H-Oxireno[k][2]benzoxacyclotetradecin-5,11(2H,4H)-dione,1a,8,9,15b-tetrahydro-3,4,12-trihydroxy-14-methoxy-9-methyl-,(1aR,3S,4S,6Z,9S,15bR)-
NSC354462
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

Hypothemycin, one of the highly oxygenated analogues in the group of 14-membered resorcylic acid lactones (RAL), has minor antifungal and cytotoxic activity and exhibits anin vitroanti-malarial activity with an IC50of 2.2 μg/mL. Hypothemycin is also reported to selectively and irreversibly inhibit protein kinases that contain a conserved cysteine residue (Cys166) that is located within the ATP-binding domain. Though this group accounts for less then 10% of all identified kinases, there are several targets implicated in aberrant cellular proliferation such as ERKs, MEK, FMS-like tyrosine kinase protein (FLT), and platelet-derived growth factor receptors (PDGFR). In cell culture, hypothemycin displays potent cytotoxicity against cancer cell lines that are dependent on certain activating kinase mutations. Additionally, hypothemycin demonstrates significant tumor growth inhibition in at least three separate murine xenograft models. Hypothemycin also inhibits the production of several cytokines such as IL2, IL6, IFNγ, and TNFα.

基本信息

经验(实验)分子式 C19H22O8
分子量 378.37
MDL编号 MFCD08457932
PubChem化学物质编号 329815176
NACRES NA.77

半岛bd体育手机客户端 性质

生物来源 Hypomyces trichothecoides
质量水平 200
测定 ≥98% (HPLC)
溶解性 DMSO: soluble
acetone: soluble
deionized water: insoluble
储存温度 ?20℃
SMILES string COc1cc(O)c2C(=O)O[C@@H](C)CC=CC(=O)[C@@H](O)[C@@H](O)CC3OC3c2c1
InChI 1S/C19H22O8/c1-9-4-3-5-12(20)17(23)14(22)8-15-18(27-15)11-6-10(25-2)7-13(21)16(11)19(24)26-9/h3,5-7,9,14-15,17-18,21-23H,4,8H2,1-2H3/b5-3-/t9-,14-,15+,17+,18+/m0/s1
InChI key SSNQAUBBJYCSMY-KNTMUCJRSA-N

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H302
预防措施声明 P301 + P312 + P330
危险分类 Acute Tox. 4 Oral
储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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