Bisindolylmaleimide X hydrochloride

半岛bd体育手机客户端 说明

应用

Bisindolylmaleimide X hydrochloride has been used as a protein kinase C (PKC) inhibitor:

• in chemotaxis assays
• to inhibit protein kinase C and to study its effects on the expression of EGR1, NAB2, ZEBRA, and Rta
• in the culture to study its effects on the expression of the kinase-insert domain-containing receptor (KDR)-B1, protein kinase Cθ (PKCθ)-M1a or Abl-HTa and on cell yield in baculovirus (BV)-infected insect cells

生化/生理作用

Bisindolylmaleimide X hydrochloride/Ro 31-8425, a strong and selective protein kinase C (PKC) inhibitor, can reduce the superoxide burst caused by various agonists in neutrophils. It can suppress the responses induced by cell surface receptors and phorbol esters in T cells. In humans, Ro 31-8425 can prevent neutrophil PKCin vitrowith an IC50 of 5nM.

基本信息

经验(实验)分子式	C26H24N4O2· HCl
分子量	460.96
MDL编号	MFCD04972010
PubChem化学物质编号	329773224
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	200
生物来源	synthetic (organic)
测定	≥90%
形式	solid
溶解性	DMSO: soluble
储存温度	?20℃
SMILES string	Cl.Cn1cc(C2=C(C(=O)NC2=O)c3c4CC(CN)CCn4c5ccccc35)c6ccccc16
InChI	1S/C26H24N4O2.ClH/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30;/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32);1H
InChI key	IMBOYWXMTUUYGZ-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)