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位置: 首页> 品牌> Sigma-Aldrich> Bisindolylmaleimide X hydrochloride

Bisindolylmaleimide X hydrochloride

品牌
Sigma-Aldrich
CAS
145317-11-9
货号
B3931
包装型号
规格纯度
≥90%, solid
价格
1306.9 *本价格含增值税费
促销
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半岛bd体育手机客户端 名称:
145317-11-9
Bisindolylmaleimide X hydrochloride
Ro 31-8425
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

Bisindolylmaleimide X hydrochloride has been used as a protein kinase C (PKC) inhibitor:

  • in chemotaxis assays
  • to inhibit protein kinase C and to study its effects on the expression of EGR1, NAB2, ZEBRA, and Rta
  • in the culture to study its effects on the expression of the kinase-insert domain-containing receptor (KDR)-B1, protein kinase Cθ (PKCθ)-M1a or Abl-HTa and on cell yield in baculovirus (BV)-infected insect cells

生化/生理作用

Bisindolylmaleimide X hydrochloride/Ro 31-8425, a strong and selective protein kinase C (PKC) inhibitor, can reduce the superoxide burst caused by various agonists in neutrophils. It can suppress the responses induced by cell surface receptors and phorbol esters in T cells. In humans, Ro 31-8425 can prevent neutrophil PKCin vitrowith an IC50 of 5nM.

基本信息

经验(实验)分子式 C26H24N4O2· HCl
分子量 460.96
MDL编号 MFCD04972010
PubChem化学物质编号 329773224
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 200
生物来源 synthetic (organic)
测定 ≥90%
形式 solid
溶解性 DMSO: soluble
储存温度 ?20℃
SMILES string Cl.Cn1cc(C2=C(C(=O)NC2=O)c3c4CC(CN)CCn4c5ccccc35)c6ccccc16
InChI 1S/C26H24N4O2.ClH/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30;/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32);1H
InChI key IMBOYWXMTUUYGZ-UHFFFAOYSA-N

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, type N95 (US)

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