γ-Secretase Inhibitor XX-CAS 209984-56-5-Calbiochem

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一般描述

A cell-permeable, potent γ-secretase inhibitor that significantly lowers both brain and plasma Aβ₄₀levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 ?mol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC₅₀= 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 andApc^Minmouse models (10 ?mol/kg, i.p).
A cell-permeable dibenzazepine (dbz) compound that acts as a potent γ-secretase inhibitor and significantly lowers both brain and plasma Aβ₄₀levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 ?mol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC₅₀= 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 andApc^Minmouse models (10 ?mol/kg, i.p).

包装

500 μg in Plastic ampoule
1 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC₅₀: 1.7 nM inhibiting Notch processing in SupT1 cells
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

其他说明

Droy-Dupré, L., et al. 2012.Dis. Model Mech.5,107.
van Es, J.H., et al. 2005.Nature435,959.
Milano, J., et al. 2004.Toxicol. Sci.82,341.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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