Eg5 Inhibitor III, Dimethylenastron-CAS 863774-58-7-Calbiochem

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一般描述

A cell-permeable quinazoline-thione compound that acts as a potent, specific, and reversible inhibitor of the microtubule-stimulated ATPase activity of the mitotic motor, Eg5 (IC₅₀= 200 nM). Exhibits little effect on the ATPase activity of kinesin-1, -4, -7 and -10 and is ~100-fold more potent than Monastrol (Cat. No. 475879). Also inhibits bipolar spindle formation in both HeLa cells and inXenopusegg extracts and induces cell cycle arrest (~1 ?M). Shown to induce mitotic arrest and apoptosis and upregulate Hsp70 in human multiple myeloma cells.
A cell-permeable quinazoline-thione compound that acts as a potent, specific, and reversible inhibitor of the microtubule-stimulated ATPase activity of the mitotic motor, Eg5 (IC₅₀= 200 nM). Exhibits little effect on the ATPase activity of kinesin-1, -4, -7 and -10 and is ~100-fold more potent than Monastrol (Cat. No. 475879). Also inhibits bipolar spindle formation in both HeLa cells and inXenopusegg extracts and induces cell cycle arrest (~1 ?M). Shown to induce mitotic arrest and apoptosis and upregulate Hsp70 in human multiple myeloma cells.

包装

1, 5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC₅₀: 200 nM inhibiting the microtubule-stimulated ATPase activity of the mitotic motor, Eg5
Primary Target
Microtubule-stimulated ATPase activity of the mitotic motor
Product does not compete with ATP.
Reversible: yes

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Liu, M., et al. 2006.J. Biol Chem.in press.
Gartner, M., et al. 2005.Chembiochem6,1173.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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