Akt Inhibitor IV-CAS 681281-88-9-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC₅₀= 625 nM) and cell proliferation (IC₅₀<1.25 M) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K. A 10 mM (1 mg/163 l) solution of Akt Inhibitor IV in DMSO is also available.
A cell-permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation presumably by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC₅₀= 625 nM) and cell proliferation (IC₅₀<1.25 ?M) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3-K.

包装

1 mg in Glass bottle
5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Target IC₅₀: 625 nM in blocking Akt-mediated FOXO1a nuclear export; <1.25 ?M in blocking Akt-mediated cell proliferation in 786-O cells
Primary Target
Akt
Reversible: yes
Cell permeable: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Kau, T.R., et al. 2003.Cancer Cell4,463.



Selected Citations
Lee, J., et al. 2009. Cell Stem Cell 5,76.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C31H27IN4S
分子量	614.54
MDL编号	MFCD00570739

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated (hygroscopic) protect from light
颜色	yellow
溶解性	DMSO: 5 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable