InSolution Q-VD-OPh, Non-O-methylated-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC₅₀= 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.

包装

5 mg in Glass bottle
1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Primary Target
caspase-1
Cell permeable: yes
Target IC₅₀: 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively
Reversible: no

警告

Toxicity: Irritant (B)

序列

Q-Val-Asp-CH?-OPh

外形

Supplied as a 10 mM (1 mg/195 ?l) solution in DMSO.

重悬

Following initial thaw, aliquot and freeze (-20°C).

其他说明

Braun, J.S., et al. 2007.Exp. Neurol.206,183.
Caserta, T.M., et al. 2003.Apoptosis8,345.
Rebbaa, A., et al. 2003.Oncogene22,2805.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C26H25F2N3O6
分子量	513.49

半岛bd体育手机客户端 性质

质量水平	100
测定	≥90% (HPLC)
形式	liquid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated (hygroscopic) protect from light
运输	wet ice
储存温度	?20℃

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 1
闪点(F)	188.6 °F - (Dimethylsulfoxide)
闪点(C)	87 ℃ - (Dimethylsulfoxide)